Helm B A, Sayers I, Swan J, Smyth L J, Cain S A, Suter M, Machado D C, Spivey A C, Padlan E A
Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, The University of Sheffield, UK.
Technol Health Care. 1998 Sep;6(2-3):195-207.
Adaptive immune responses characterised by the synthesis of antibodies of the immunoglobulin E (IgE) isotype play an important role in type I hypersensitivity disorders and parasitic infestations, diseases which have an significant socioeconomic impact world-wide. This paper considers potential applications of recent advances in our understanding of the origin of isotype specific immune responses which emerged as a result of cell and protein engineering studies on components of the human IgE/receptor/effector system. Furthermore, the identification of the receptor binding regions in IgE as a result of the development of a stable assay system has important applications for the design of rational therapeutic interventions in allergy and asthma, the treatment of mast cell tumours, and the establishment of procedures for the selective isolation of cells expressing the high-affinity receptor for IgE for functional studies.
以免疫球蛋白E（IgE）同种型抗体的合成为特征的适应性免疫反应在I型超敏反应性疾病和寄生虫感染中起重要作用，这些疾病在全球范围内具有重大的社会经济影响。本文探讨了我们对同种型特异性免疫反应起源的最新认识进展的潜在应用，这些进展源于对人类IgE/受体/效应系统成分的细胞和蛋白质工程研究。此外，由于开发了稳定的检测系统而确定了IgE中的受体结合区域，这对于设计合理的过敏和哮喘治疗干预措施、治疗肥大细胞瘤以及建立用于选择性分离表达IgE高亲和力受体的细胞以进行功能研究的程序具有重要应用价值。
