西沙必利对糖尿病患者胆囊收缩的作用。

Action of cisapride on gallbladder contraction in patients with diabetes mellitus.

作者信息

Kapicioglu S, Senturk O, Bambul N, Ilgun K

机构信息

Blacksea Technical University, School of Medicine, Department of Internal Medicine, Trabzon, Turkey.

出版信息

Hepatogastroenterology. 1998 Sep-Oct;45(23):1410-4.

PMID:9840075

Abstract

BACKGROUND/AIMS: Gallbladder emptying abnormalities are common in patients with diabetes mellitus, and it has been hypothesized that they contribute to the increased incidence of gallbladder stones and biliary pain observed in these patients. Cisapride is a drug that exerts a prokinetic effect in both animals and humans. Recently, we demonstrated that cisapride decreased the fasting and post-prandial gallbladder volume in healthy subjects. Therefore, we investigated the action of cisapride on gallbladder contraction in diabetic patients.

METHODOLOGY

Twenty diabetes mellitus patients and 20 healthy volunteers participated in this study. On the day of the study, ultrasonography was performed at 9 am, after 12 hours of fasting. After the basal measurement was obtained, the diabetic patients and healthy subjects received 10 mg cisapride or a placebo peroral. Two hours later, gallbladder volumes were rescanned by ultrasonography at 15-minute intervals for 60 minutes.

RESULTS

The fasting gallbladder volume was 19.8 +/- 6.7 ml in the diabetic patients, and after the administration of cisapride, the gallbladder volume decreased by 32.2%-38.6% as compared to the baseline (p<0.02, 0.05, 0.01) and by 35.0%-45.8% as compared to the diabetic controls (p<0.02, 0.05, 0.001). In the healthy subjects, cisapride did not change the fasting mean gallbladder volume as compared to the baseline. After the administration of cisapride in the diabetic patients, the mean gallbladder volume decreased more than in the healthy subjects. The mean gallbladder volumes of the diabetic patients were between 12.1 +/- 4.2-13.4 +/- 4.2 ml. In the healthy volunteers, after the administration of cisapride, the volume was reduced by 1.9%-11.3% as compared to the healthy control group, but the volume changes of these two groups were not statistically significant.

CONCLUSION

This study shows that the administration of cisapride causes gallbladder volume reduction in diabetic patients.

摘要

背景/目的：胆囊排空异常在糖尿病患者中很常见，据推测，这会导致这些患者胆囊结石和胆绞痛的发病率增加。西沙必利是一种在动物和人类中均具有促动力作用的药物。最近，我们证明西沙必利可降低健康受试者空腹和餐后的胆囊体积。因此，我们研究了西沙必利对糖尿病患者胆囊收缩的作用。

方法

20例糖尿病患者和20名健康志愿者参与了本研究。在研究当天，禁食12小时后于上午9点进行超声检查。在获得基础测量值后，糖尿病患者和健康受试者口服10mg西沙必利或安慰剂。两小时后，每隔15分钟通过超声检查重新扫描胆囊体积，持续60分钟。

结果

糖尿病患者空腹胆囊体积为19.8±6.7ml，服用西沙必利后，胆囊体积与基线相比下降了32.2%-38.6%（p<0.02、0.05、0.01），与糖尿病对照组相比下降了35.0%-45.8%（p<0.02、0.05、0.001）。在健康受试者中，与基线相比，西沙必利未改变空腹时的平均胆囊体积。糖尿病患者服用西沙必利后，平均胆囊体积的下降幅度大于健康受试者。糖尿病患者的平均胆囊体积在12.1±4.2-13.4±4.2ml之间。在健康志愿者中，服用西沙必利后，与健康对照组相比，体积减少了1.9%-11.3%，但这两组的体积变化无统计学意义。