Herbst J J, Johnson D G, Oliveros M A
Am J Dis Child. 1976 Nov;130(11):1256-8. doi: 10.1001/archpedi.1976.02120120090017.
Finger clubbing, protein-losing enteropathy, and iron deficiency were documented in three children with severe gastroesophageal reflux. One patient had Sandifer syndrome and the other two had the rumination syndrome. In each case, surgical repair of the gastroesophageal reflux resulted in immediate clearing of signs of the Sandifer syndrome, gastroesophageal reflux, and anemia and the return of serum protein levels to normal. There was definite regression of the finger clubbing during the ensuing year. It is suggested that finger clubbing, protein-losing enteropathy, Sandifer syndrome, and rumination be viewed as parts of an extended syndrome of unusual presentations of gastroesophageal reflux.
在三名患有严重胃食管反流的儿童中记录到杵状指、蛋白丢失性肠病和缺铁。一名患者患有桑迪弗综合征，另外两名患有反刍综合征。在每种情况下，胃食管反流的手术修复都能立即消除桑迪弗综合征、胃食管反流和贫血的症状，并使血清蛋白水平恢复正常。在随后的一年中，杵状指明显消退。建议将杵状指、蛋白丢失性肠病、桑迪弗综合征和反刍视为胃食管反流异常表现的扩展综合征的一部分。
