Del Pozo M A, Arias J R, Pinilla J, Labarga P, Alcoba M, Martinez de la Cruz F J, Anton F, Carro J A, Perez M R, Echevarria S, Garrote E, Moreno-Otero R
Unit of Infectious Diseases, Hospital Clinico Universitario, Valladolid, Spain.
Hepatogastroenterology. 1998 Sep-Oct;45(23):1695-701.
BACKGROUND/AIMS: In our area most of the human immunodeficiency virus (HIV) infected patients are intravenous drug users; HIV and hepatitis C virus infections often coexist in these patients. Due to the repercussions of both infections, we designed a trial to evaluate the efficacy, response-related factors and tolerance during an eight-month regime of recombinant interferon alpha-2b on hepatitis C virus infection.
We included 79 patients in an open, prospective and multicentric trial with zidovudine and interferon alpha-2b. Response to interferon treatment was evaluated by biochemical and histopathological criteria.
A complete response (alanine aminotransferase normalization) was obtained in 57.4% of patients. The significant response-related factors were: degree of histopathological activity, CD4+ cell number and initial leukocyte number.
Recombinant interferon therapy seems to be effective for chronic hepatitis C in HIV infected patients; the best response was in those with active chronic hepatitis and CD4+ cell counts > or = 200/mm3. General tolerance was variable, although side effects were not different from those seen in non-HIV patients. The most common side effect was flu-like syndrome (constitutional manifestations), with no interference on treatment continuity; however, hematological toxicity prevents the indiscriminate use of interferon.
背景/目的：在我们地区，大多数人类免疫缺陷病毒（HIV）感染患者为静脉吸毒者；HIV和丙型肝炎病毒感染在这些患者中常常并存。鉴于这两种感染所带来的影响，我们设计了一项试验，以评估重组干扰素α-2b治疗丙型肝炎病毒感染8个月疗程中的疗效、反应相关因素及耐受性。
我们将79例患者纳入一项使用齐多夫定和干扰素α-2b的开放、前瞻性、多中心试验。通过生化和组织病理学标准评估对干扰素治疗的反应。
57.4%的患者获得完全缓解（丙氨酸转氨酶正常化）。显著的反应相关因素为：组织病理学活动度、CD4+细胞数量及初始白细胞数量。
重组干扰素治疗对HIV感染患者的慢性丙型肝炎似乎有效；最佳反应见于慢性活动性肝炎且CD4+细胞计数≥200/mm3的患者。总体耐受性各不相同，尽管副作用与非HIV患者所见无异。最常见的副作用是流感样综合征（全身表现），对治疗的连续性无干扰；然而，血液学毒性妨碍了干扰素的随意使用。
