Grieco A, Matera A, Di Rocco P, Marcoccia S, Giancaterini A, Alfei B, Addolorato G, Varlese F, Gasbarrini G
Istituto di Medicina Interna e Geriatria, Universita Cattolica S. Cuore, Policlinico Universitario A.Gemelli, Roma, Italy.
Hepatogastroenterology. 1998 Sep-Oct;45(23):1731-6.
BACKGROUND/AIMS: Plasma fibronectin levels are reportedly decreased in patients with cirrhosis, while increases are associated with acute and chronic hepatitis. We studied 101 patients with chronic liver disease to determine the relationship between disease etiology and plasma fibronectin levels.
Plasma fibronectin levels and standard liver function parameters were measured in all patients and 11 healthy controls. Antipyrine metabolism was also evaluated in 39 patients. Results were analyzed according to etiology (HBV, HCV, alcohol abuse) and histological findings (chronic active hepatitis (CAH) with/without fibrosis, steatosis, cirrhosis).
The fibronectin levels were similar in patients with HBV, HCV and alcohol-related disease. Analysis of the groups based on histological features showed that fibronectin levels in cirrhotics (mean 270.69 microg/ml) were significantly lower than those of the control (mean 372.00 microg/ml) and other patient groups (steatosis: 470.37 microg/ml; CAH: 417.93 microg/ml; CAH and fibrosis: 426.72 microg/ml). Plasma fibronectin displayed a positive correlation with antipyrine metabolism and parameters of hepatic synthesis.
Plasma fibronectin appears to be an index of hepatic parenchymal function but shows no relation to the etiology of the liver disease.
背景/目的：据报道，肝硬化患者血浆纤连蛋白水平降低，而急慢性肝炎患者血浆纤连蛋白水平升高。我们研究了101例慢性肝病患者，以确定疾病病因与血浆纤连蛋白水平之间的关系。
检测了所有患者和11名健康对照者的血浆纤连蛋白水平及标准肝功能参数。还对39例患者进行了安替比林代谢评估。根据病因（乙肝病毒、丙肝病毒、酒精滥用）和组织学结果（伴有/不伴有纤维化、脂肪变性、肝硬化的慢性活动性肝炎）分析结果。
乙肝病毒、丙肝病毒感染及酒精相关疾病患者的纤连蛋白水平相似。基于组织学特征的分组分析显示，肝硬化患者的纤连蛋白水平（平均270.69微克/毫升）显著低于对照组（平均372.00微克/毫升）和其他患者组（脂肪变性：470.37微克/毫升；慢性活动性肝炎：417.93微克/毫升；慢性活动性肝炎伴纤维化：426.72微克/毫升）。血浆纤连蛋白与安替比林代谢及肝脏合成参数呈正相关。
血浆纤连蛋白似乎是肝实质功能的一个指标，但与肝病病因无关。
