全身麻醉是否会通过β-N-乙酰己糖胺酶血清活性水平来影响肝血窦细胞？
Does general anesthesia affect sinusoidal liver cells as measured by beta-N-acetyl hexosaminidase serum activity level?
作者信息
Scapa E, Pinhasov I, Eshchar J
机构信息
Institute of Gastroenterology, Liver Diseases and Nutrition, Assaf Harofeh Medical Center, Zerifin, Israel.
出版信息
Hepatogastroenterology. 1998 Sep-Oct;45(23):1813-5.
BACKGROUND/AIMS: General anesthesia causes temporary hypoxia of liver tissue, resulting in several metabolic changes. The purpose of this study was to explore whether the function of hepatic sinusoidal cells, especially the Kupffer and endothelial cells, are damaged following general anesthesia.
METHODOLOGY
Liver sinusoidal cell (LSC) function was evaluated by means of measuring the serum level of activity of the lysosomal hydrolase beta-N-acetyl hexosaminidase before and 24 hours after general anesthesia in 20 patients who underwent orthopedic surgery.
RESULTS
The only change in liver function which might be of clinical significance was a mild decline in the serum albumin level.
CONCLUSIONS
Liver sinusoidal cells, especially Kupffer and endothelial cells, most probably remain undamaged after 1 to 5 hours of general anesthesia.
背景/目的：全身麻醉会导致肝组织暂时缺氧，从而引发一些代谢变化。本研究的目的是探讨全身麻醉后肝窦细胞，尤其是库普弗细胞和内皮细胞的功能是否受损。
方法
通过测量20例接受骨科手术患者在全身麻醉前和麻醉后24小时的溶酶体水解酶β-N-乙酰氨基己糖苷酶的血清活性水平，评估肝窦细胞（LSC）功能。
结果
肝功能方面唯一可能具有临床意义的变化是血清白蛋白水平略有下降。
结论
全身麻醉1至5小时后，肝窦细胞，尤其是库普弗细胞和内皮细胞很可能未受损伤。
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