Nguyen U N, Mougin F, Simon-Rigaud M L, Rouillon J D, Marguet P, Regnard J
Laboratoire de Physiologie - Explorations Fonctionnelles Rénales et Métaboliques, Centre Hospitalier Universaire, Besançon, France.
Eur J Appl Physiol Occup Physiol. 1998 Nov;78(6):533-7. doi: 10.1007/s004210050456.
The changes in circulating concentrations of insulin-like growth factors during exercise have to date remained incomplete in their documentation. Therefore, we examined in 25 healthy athletes the effects of three different durations of three types of exercise -- incremental ergometer cycling exercise (ICE), long-distance Nordic ski race (NSR) and a treadmill-simulated soccer game (TSG) lasting 20 min, 3 h, and 2 x 45 min separated by a 15-min half-time rest respectively, on plasma concentrations of growth hormone ([GH]), insulin-like growth factor-1 ([IGF-I]) and its binding proteins 1 and 3 ([IGFBP-1], [IGFBP-3]). Compared to baseline, serum [GH] increased by 15.2-fold after ICE (P < 0.001), 2.9-fold after NSR (P < 0.01) and 4.6-fold after TSG. Serum [IGF-I] rose by 11.9% after ICE (P < 0.001), while it decreased by -14.6% after NSR (P < 0.001) and was unchanged after TSG. Serum [IGFBP-1] was slightly increased (1.7-fold) after ICE (P < 0.01), but increased markedly (11.8-fold) after NSR (P < 0.001) and by 6.3-fold after the second session of TSG (P < 0.01) (it remained unchanged at the end of the first period of TSG, i.e. after 45-min exercise). The [IGFBP-3] increased by 14.7% after ICE (P < 0.001) and by 6% after TSG (P < 0.05) while it did not change after NSR. From our results it would appear that [IGFBP-1] increase to bind free IGF and hinder their insulin-like action during long-term exercise (lasting beyond 45 min). It is suggested that IGFBP-1 might thus contribute both to preventing hypoglycaemic action of IGF and to facilitating glucose uptake by muscle cells when muscle glycogen stores become deplete.
迄今为止，运动期间循环中胰岛素样生长因子浓度的变化情况仍记录不完整。因此，我们对25名健康运动员进行了研究，观察三种不同类型且持续时间各异的运动——分别为持续20分钟的递增功率计骑行运动（ICE）、持续3小时的北欧式长距离滑雪比赛（NSR）以及持续2×45分钟且中间有15分钟中场休息的跑步机模拟足球比赛（TSG），对血浆中生长激素（[GH]）、胰岛素样生长因子-1（[IGF-I]）及其结合蛋白1和3（[IGFBP-1]、[IGFBP-3]）浓度的影响。与基线相比，ICE后血清[GH]升高了15.2倍（P < 0.001），NSR后升高了2.9倍（P < 0.01），TSG后升高了4.6倍。ICE后血清[IGF-I]升高了11.9%（P < 0.001），而NSR后降低了-14.6%（P < 0.001），TSG后无变化。ICE后血清[IGFBP-1]略有升高（1.7倍）（P < 0.01），但NSR后显著升高（11.8倍）（P < 0.001），TSG第二场后升高了6.3倍（P < 0.01）（TSG第一场结束时，即45分钟运动后，其保持不变）。ICE后[IGFBP-3]升高了14.7%（P < 0.001），TSG后升高了6%（P < 0.05），而NSR后无变化。从我们的结果来看，在长期运动（持续超过45分钟）期间，[IGFBP-1]升高以结合游离的IGF并阻碍其胰岛素样作用。由此表明，IGFBP-1可能既有助于防止IGF的降血糖作用，又有助于在肌肉糖原储备耗尽时促进肌肉细胞对葡萄糖的摄取。
