Manetta Jérôme, Brun Jean Frederic, Maimoun Laurent, Callis Albert, Préfaut Christian, Mercier Jacques
Service Central de Physiologie Clinique: Centre d'Exploration et de Réadaptation des Anomalies Métaboliques et Musculaires, hôpital Lapeyronie, 34295 Montpellier, France.
Am J Physiol Endocrinol Metab. 2002 Nov;283(5):E929-36. doi: 10.1152/ajpendo.00539.2001.
The aim of this study was to compare circulating levels of growth hormone (GH), IGF-I, and IGF-binding protein (IGFBP)-1 and IGFBP-3 in response to a long-duration endurance exercise in trained vs. sedentary middle-aged males and to determine whether a relationship with glucose homeostasis exists. Seven trained men (Tr) were compared with seven age-matched sedentary men (Sed) during two trials of 60 min of cycling exercise performed below (-VT) and above (+VT) the ventilatory threshold. Insulin sensitivity (S(I)) was higher in Tr than in Sed (P < 0.001). Basal GH, IGF-I, and IGFBP-1 and -3 were higher in Tr (P < 0.05). During +VT, Tr had a threefold higher GH response, whereas their blood glucose level was better maintained (P < 0.05). Basal IGFBP-1 was correlated with S(I) (P < 0.01). These data indicate that endurance training in middle-aged men increased the activity of the GH/IGF-I system and improved glucoregulation both at rest and during high-intensity endurance exercise.
本研究旨在比较训练有素的中年男性与久坐不动的中年男性在长时间耐力运动后生长激素（GH）、胰岛素样生长因子-I（IGF-I）以及IGF结合蛋白（IGFBP）-1和IGFBP-3的循环水平，并确定其与葡萄糖稳态是否存在关联。在两次分别为60分钟的骑行运动试验中，将7名训练有素的男性（Tr）与7名年龄匹配的久坐男性（Sed）进行比较，运动强度分别低于通气阈值（-VT）和高于通气阈值（+VT）。Tr组的胰岛素敏感性（S(I)）高于Sed组（P < 0.001）。Tr组的基础GH、IGF-I以及IGFBP-1和-3水平更高（P < 0.05）。在+VT运动期间，Tr组的GH反应高出三倍，而其血糖水平得到更好维持（P < 0.05）。基础IGFBP-1与S(I)相关（P < 0.01）。这些数据表明，中年男性进行耐力训练可增强GH/IGF-I系统的活性，并改善静息状态及高强度耐力运动期间的糖代谢调节。
