密歇根州蒂卡姆西血清胆固醇变异的遗传和环境来源分析。III. 使用12种多态性遗传血液标记系统鉴定遗传效应。
Analysis of genetic and environmental sources of variation in serum cholesterol in Tecumseh, Michigan. III. Identification of genetic effects using 12 polymorphic genetic blood marker systems.
作者信息
Sing C F, Orr J D
出版信息
Am J Hum Genet. 1976 Sep;28(5):453-64.
Abstract
Four of 12 unlinked polymorphic marker systems were identified as predictors of normal serum cholesterol levels. Consistent effects between males and females and with other studies suggest that these marker loci are themselves involved in cholesterol determination or are closely linked to the involved loci. Two-locus combinations suggest that an 8-9 mg/100 ml difference in nonfasting serum cholesterol may be predicted between phenotypic classes which are not rare in frequency.
摘要
12个不连锁的多态性标记系统中有4个被确定为正常血清胆固醇水平的预测指标。男性和女性之间以及与其他研究的一致结果表明，这些标记位点本身参与胆固醇的测定，或者与相关位点紧密连锁。两位点组合表明，在频率上并不罕见的表型类别之间，非空腹血清胆固醇可能存在8 - 9 mg/100 ml的差异。
相似文献
1
2
3
Analysis of genetic and environmental sources of variation in serum cholesterol in Tecumseh, Michigan--VI. A search for genotype by environment interaction.密歇根州蒂卡姆西血清胆固醇变异的遗传和环境来源分析——VI. 探索基因型与环境的相互作用
J Chronic Dis. 1981;34(11):545-59. doi: 10.1016/0021-9681(81)90017-5.
4
5
6
Analysis of genetic and environmental sources of variation in serum cholesterol in Tecumseh, Michigan. V. Variance components estimated from pedigrees.密歇根州蒂卡姆西血清胆固醇变异的遗传和环境来源分析。V. 从家系估计的方差成分。
Ann Hum Genet. 1979 Jan;42(3):343-54. doi: 10.1111/j.1469-1809.1979.tb00668.x.
7
Analysis of genetic and environmental sources of variation in serum cholesterol in Tecumseh, Michigan: II. The role of education, occupation, and income.密歇根州蒂卡姆西血清胆固醇变异的遗传和环境来源分析：II. 教育、职业和收入的作用。
Soc Biol. 1975 Spring;22(1):34-43. doi: 10.1080/19485565.1975.9988145.
8
The Tecumseh Community Health Study.蒂康西社区健康研究
Prog Clin Biol Res. 1984;147:37-42.
9
The effect of sample attrition on the frequency distribution of blood pressure and genetic marker phenotypes representing a natural unselected community: Tecumseh, Michigan.样本损耗对代表自然未选择社区（密歇根州蒂尔西特）的血压和遗传标记表型频率分布的影响。
Am J Phys Anthropol. 1976 Jan;44(1):139-49. doi: 10.1002/ajpa.1330440120.
10
DISTRIBUTIONS AND FAMILIAL STUDIES OF BLOOD PRESSURE AND SERUM CHOLESTEROL LEVELS IN A TOTAL COMMUNITY--TECUMSEH, MICHIGAN.密歇根州蒂卡姆西一个完整社区的血压和血清胆固醇水平分布及家族研究
J Chronic Dis. 1965 Feb;18:147-60. doi: 10.1016/0021-9681(65)90098-6.
引用本文的文献
1
Frequent detection of familial hypercholesterolemia mutations in familial combined hyperlipidemia.在家族性混合性高脂血症中频繁检测到家族性高胆固醇血症突变。
J Am Coll Cardiol. 2008 Nov 4;52(19):1554-6. doi: 10.1016/j.jacc.2008.08.012.
2
Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women.ABO组织血型抗原与可溶性细胞间黏附分子-1的新型关联：一项对6578名女性的全基因组关联研究结果
PLoS Genet. 2008 Jul 4;4(7):e1000118. doi: 10.1371/journal.pgen.1000118.
3
Extended multipoint identity-by-descent analysis of human quantitative traits: efficiency, power, and modeling considerations.人类数量性状的扩展多点同源分析：效率、效能及建模考量
Am J Hum Genet. 1993 Dec;53(6):1306-19.
4
5
The contribution of quantitative trait loci and neutral marker loci to the genetic variances and covariances among quantitative traits in random mating populations.数量性状基因座和中性标记基因座对随机交配群体中数量性状间遗传方差和协方差的贡献。
Genetics. 1995 Jan;139(1):445-55. doi: 10.1093/genetics/139.1.445.
6
Detection of genetic heterogeneity among pedigrees through complex segregation analysis: an application to hypercholesterolemia.通过复杂分离分析检测家系间的遗传异质性：在高胆固醇血症中的应用。
Am J Hum Genet. 1984 Jan;36(1):197-211.
7
A defense of path analysis in genetic epidemiology.遗传流行病学中路径分析的辩护。
Am J Hum Genet. 1983 Jul;35(4):733-56.
8
Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation.载脂蛋白E基因多态性在决定正常血浆脂质和脂蛋白变异中的作用。
Am J Hum Genet. 1985 Mar;37(2):268-85.
9
Rapid typing of tandemly repeated hypervariable loci by the polymerase chain reaction: application to the apolipoprotein B 3' hypervariable region.通过聚合酶链反应对串联重复高变区进行快速分型：应用于载脂蛋白B 3'高变区。
Proc Natl Acad Sci U S A. 1989 Jan;86(1):212-6. doi: 10.1073/pnas.86.1.212.
本文引用的文献
1
Field methods and response rates in the Tecumseh community health study.蒂卡姆西社区健康研究中的现场方法与应答率
Am J Public Health Nations Health. 1962 Feb;52(2):208-16. doi: 10.2105/ajph.52.2.208.
2
EPIDEMIOLOGICAL STUDIES OF CARDIOVASCULAR DISEASE IN A TOTAL COMMUNITY--TECUMSEH, MICHIGAN.密歇根州蒂卡姆西整个社区心血管疾病的流行病学研究
Ann Intern Med. 1965 Jun;62:1170-87. doi: 10.7326/0003-4819-62-6-1170.
3
SERUM-ALKALINE-PHOSPHATASE AND THE ABO BLOOD-GROUPS.血清碱性磷酸酶与ABO血型
Lancet. 1965 Mar 6;1(7384):530-1. doi: 10.1016/s0140-6736(65)92027-1.
4
Influence of diet on the "intestinal" component of serum alkaline phosphatase in people of different ABO blood groups and secretor status.饮食对不同ABO血型和分泌状态人群血清碱性磷酸酶“肠道”成分的影响。
Nature. 1966 Oct 1;212(5057):41-3. doi: 10.1038/212041a0.
5
Genetic influences on serum cholesterol in two Greek villages.希腊两个村庄中基因对血清胆固醇水平的影响。
Hum Hered. 1969;19(1):86-99. doi: 10.1159/000152204.
6
Blood groups and serum cholesterol among 10,000 adult males.一万名成年男性的血型与血清胆固醇
Atherosclerosis. 1971 Sep-Oct;14(2):219-29. doi: 10.1016/0021-9150(71)90051-7.
7
8
A search for associations between genetical polymorphic systems and physical, biochemical and Haematological variables.探索基因多态性系统与物理、生化及血液学变量之间的关联。
Hum Hered. 1974;24(5-6):424-34. doi: 10.1159/000152679.
9
A relationship between plasma cholesterol level, latitude, and the Rhesus blood group system.血浆胆固醇水平、纬度与恒河猴血型系统之间的关系。
Hum Biol. 1974 Dec;46(4):641-6.
10
Serum-cholesterol and ABO and Lewis blood-groups.血清胆固醇与ABO及Lewis血型
Lancet. 1970 May 9;1(7654):1000. doi: 10.1016/s0140-6736(70)91123-2.
Zotero 插件