De Felici M, Pesce M, Giustiniani Q, Di Carlo A
Department of Public Health and Cell Biology, University of Rome Tor Vergata, Italy.
Microsc Res Tech. 1998 Nov 1;43(3):258-64. doi: 10.1002/(SICI)1097-0029(19981101)43:3<258::AID-JEMT8>3.0.CO;2-1.
Adhesive interactions with the surrounding cells and extracellular matrix components are crucial for migration and development of primordial germ cells. The possibility of isolating and culturing such cells from the mouse embryo has allowed the initial characterization of their adhesion properties, and the identification of some adhesion molecules. Furthermore, it has permitted us to obtain indications of the role that signals from adhesion receptors present on primordial germ cell surface play in regulating their migration, growth, and possibly differentiation. In the present review, we summarize this progress with particular emphasis on the contribution provided by microscopic studies performed on isolated mouse primordial germ cells cultured on various substrata.
与周围细胞和细胞外基质成分的黏附相互作用对于原始生殖细胞的迁移和发育至关重要。从小鼠胚胎中分离和培养此类细胞的可能性，使得对其黏附特性进行初步表征以及鉴定一些黏附分子成为可能。此外，这还使我们能够了解原始生殖细胞表面存在的黏附受体发出的信号在调节其迁移、生长以及可能的分化过程中所起的作用。在本综述中，我们总结了这一进展，特别强调了对培养在各种基质上的分离小鼠原始生殖细胞进行显微镜研究所做出的贡献。
