Novelli E L, Vieira E P, Rodrigues N L, Ribas B O
Department of Chemistry, University Estadual Paulista, UNESP, Botucatu, São Paulo, 18618-000, Brazil.
Environ Res. 1998 Nov;79(2):102-5. doi: 10.1006/enrs.1998.3865.
Pollution and industrial practices result in concentrations of metals and other environmental agents that are related to environmental toxicity. A rat bioassay was utilized for the identification of toxic effects of cadmium intake. This demonstrated increased total urinary proteins and increased kidney weights in rats exposed to CdCl2 for 7 days, in drinking water (100 mg/L). Serum creatinine, total and direct bilirubin concentrations and alanine transaminase activity were increased in Cd-exposed rats, indicating renal and hepatic toxicity. It was also observed that lipoperoxide concentrations were increased, while Cu-Zn superoxide dismutase activity was decreased in rats treated with cadmium. This indicated that the renal and hepatic toxicity induced by cadmium involved superoxide radicals.
污染和工业活动导致金属及其他环境因子的聚集，这些与环境毒性相关。采用大鼠生物测定法来鉴定镉摄入的毒性作用。结果表明，饮用含100毫克/升氯化镉的水7天的大鼠，其尿总蛋白增加，肾脏重量增加。镉暴露大鼠的血清肌酐、总胆红素和直接胆红素浓度以及丙氨酸转氨酶活性均升高，表明存在肾毒性和肝毒性。还观察到，镉处理的大鼠体内脂过氧化物浓度升高，而铜锌超氧化物歧化酶活性降低。这表明镉诱导的肾毒性和肝毒性涉及超氧自由基。
