Epelbaum J, Dournaud P
U159 INSERM, Centre Paul Broca, Paris.
C R Seances Soc Biol Fil. 1998;192(4):597-606.
Somatostatin (SRIF) was discovered in 1973, in Roger Guillemin's laboratory as a Growth Hormone (GH) inhibiting neurohormone. It is widely distributed in mammals where it acts also as a peripheral hormone, an autocrine or paracrine factor and a neuropeptide. SRIF receptors are located on several human tumours and SRIF agonists are in clinical use to monitor GH secretion in acromegalic patients. This short review summarizes the properties of the central and peripheral somatostatinergic systems, the three peptides belonging to the somatostatin family: (SRIF14, SRIF28 and cortistatin), the pharmacology of the five SRIF receptor subtypes, some ontogenetic and phylogenetic aspects, as well as pathological findings.
生长抑素（SRIF）于1973年在罗杰·吉耶曼的实验室被发现，是一种抑制生长激素（GH）的神经激素。它广泛分布于哺乳动物体内，在其中还作为一种外周激素、自分泌或旁分泌因子以及神经肽发挥作用。生长抑素受体位于多种人类肿瘤上，生长抑素激动剂在临床上用于监测肢端肥大症患者的生长激素分泌。这篇简短综述总结了中枢和外周生长抑素能系统的特性、属于生长抑素家族的三种肽（SRIF14、SRIF28和皮质抑素）、五种生长抑素受体亚型的药理学、一些个体发生和系统发育方面以及病理发现。
