单侧前庭去传入在豚鼠外侧前庭核而非内侧前庭核中诱导脑源性神经营养因子（BDNF）蛋白表达。
Unilateral vestibular deafferentation induces brain-derived neurotrophic factor (BDNF) protein expression in the guinea pig lateral but not medial vestibular nuclei.
作者信息
Smith P F, Darlington C L, Yan Q, Dragunow M
机构信息
Department of Pharmacology, School of Medical Sciences, University of Otago Medical School, Dunedin, New Zealand.
出版信息
J Vestib Res. 1998 Nov-Dec;8(6):443-7.
The aim of the present study was to investigate the expression of the neurotrophin, brain-derived neurotrophic factor (BDNF), in the vestibular nucleus complex (VNC) following unilateral vestibular deafferentation (UVD). Using immunohistochemistry, BDNF expression was analyzed in the bilateral VNC of the guinea pig in sham animals, and immediately, 10 h, and 50 h post-UVD. No BDNF expression was seen in the VNC in sham animals or immediately or 10 h post-UVD. However, at 50 h post-UVD, clear BDNF expression was seen in the bilateral lateral vestibular nuclei (LVN) and in the bilateral abducens nuclei, but not in the medial vestibular nuclei (MVN). The significance of this late BDNF expression is nuclear.
本研究的目的是调查单侧前庭神经切断术（UVD）后神经营养因子脑源性神经营养因子（BDNF）在前庭神经核复合体（VNC）中的表达情况。采用免疫组织化学方法，分析了假手术动物以及UVD后即刻、10小时和50小时豚鼠双侧VNC中BDNF的表达。在假手术动物、UVD后即刻或10小时的VNC中均未观察到BDNF表达。然而，在UVD后50小时，双侧外侧前庭核（LVN）和双侧展神经核中可见明显的BDNF表达，而在内侧前庭核（MVN）中未见表达。这种BDNF延迟表达的意义有待进一步探讨。
Zotero 插件