Robert A M, Robert L
Laboratoire de Recherche Ophtalmologique, Hôpital Hôtel-Dieu, Paris.
Pathol Biol (Paris). 1998 Sep;46(7):535-42.
The blood-brain barrier (BBB) is a functional characteristic of the cerebral microvasculature that determines which molecules can travel from the bloodstream to the brain parenchyma and vice versa. During the last few decades, we have investigated the contribution of vascular extracellular matrix (ECM) to BBB function. The present review analyzes our findings in the light of recent data on age-related brain function alterations and discusses the potential contribution of BBB function impairment to the processes that determine these alterations.
血脑屏障（BBB）是脑微血管的一种功能特性，它决定了哪些分子能够从血液进入脑实质，反之亦然。在过去几十年里，我们研究了血管细胞外基质（ECM）对血脑屏障功能的作用。本综述根据近期有关年龄相关脑功能改变的数据，分析了我们的研究结果，并讨论了血脑屏障功能受损对决定这些改变的过程的潜在影响。
