血浆戊巴比妥水平。制剂、给药途径和方法的影响。

Plasma pentobarbitone levels. Influence of the preparation, route and method of administration.

作者信息

Nair S G, Dundee J W, Clarke R S, Howard P J

出版信息

Anaesthesia. 1976 Oct;31(8):1037-42. doi: 10.1111/j.1365-2044.1976.tb11941.x.

DOI:10.1111/j.1365-2044.1976.tb11941.x

Abstract

In fit women plasma pentobarbitone was measured by gas-liquid chromatography after 100 mg given by mouth or intramuscular injection in the buttock using aqueous and organic solutions. Differences in plasma levels with the two solutions were not striking. Considerable inter-administrator difference occurred with significantly higher plasma levels when the drug was injected by a doctor using a 4 cm 21 s.w.g. needle as compared with nurses who used no specified injection technique. The oral route gave significantly higher plasma levels than nurse-given injections.

摘要

在健康女性中，口服或臀部肌肉注射100毫克戊巴比妥后，使用水性和有机溶液，通过气液色谱法测定血浆中的戊巴比妥。两种溶液的血浆水平差异不显著。当医生使用4厘米21号规格的针头注射药物时，血浆水平显著高于未采用特定注射技术的护士，管理人员之间存在相当大的差异。口服途径产生的血浆水平显著高于护士注射。