脊椎动物的体节形成：生物钟与Notch信号通路相关联。
Vertebrate segmentation: the clock is linked to Notch signalling.
作者信息
Jiang Y J, Smithers L, Lewis J
机构信息
Vertebrate Development Laboratory Imperial Cancer Research Fund 44 Lincoln's Inn Fields London WC2A 3PX UK.
出版信息
Curr Biol. 1998 Dec 3;8(24):R868-71. doi: 10.1016/s0960-9822(07)00547-7.
PMID:9843676
Abstract
The periodic formation of somites during vertebrate segmentation has been suggested to involve a molecular 'segmentation clock'. Recent observations of cyclic Lunatic fringe expression in chick and mouse embryos link the segmentation clock to Delta-Notch signalling.
摘要
脊椎动物分节过程中体节的周期性形成被认为涉及一种分子“分节时钟”。最近在鸡和小鼠胚胎中对周期性表达的Lunatic fringe的观察将分节时钟与Delta-Notch信号传导联系起来。
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