Rehse K, Shahrouri T
Institut für Pharmazie I, Freie Universität Berlin, Germany.
Arch Pharm (Weinheim). 1998 Oct;331(10):308-12. doi: 10.1002/(sici)1521-4184(199810)331:10<308::aid-ardp308>3.3.co;2-u.
Suitable hydrazines like phenylhydrazine (1), N,N-dimethyl hydrazine (4), and N,N-diphenyl hydrazine (5) can be oxidized by hydrogen peroxide at pH 7.4 and 37 degrees C to nitrosohydrogen and further to nitrite and nitrate. The extent of this property is correlated with platelet aggregation inhibiting and antithrombotic effects of these compounds, suggesting that an NO mediated mechanism might be involved. All hydrazines tested and two N-ethoxycarbonyl prodrugs exhibited antihypertensive effects which were not correlated to the above properties. This is especially pronounced in hydralazine (6) and dihydralazine (7) which induced a strong decrease in blood pressure but exhibit neither antiplatelet nor antithrombotic effects. This indicates that the mechanism of the antihypertensive activity is different from that of the antiplatelet activity.
合适的肼类化合物，如苯肼（1）、N，N-二甲基肼（4）和N，N-二苯基肼（5），在pH值为7.4、温度为37℃的条件下可被过氧化氢氧化为亚硝基氢，进而氧化为亚硝酸盐和硝酸盐。这种性质的程度与这些化合物的血小板聚集抑制和抗血栓形成作用相关，表明可能涉及一氧化氮介导的机制。所有测试的肼类化合物和两种N-乙氧羰基前药均表现出降压作用，这与上述性质无关。这在肼屈嗪（6）和双肼屈嗪（7）中尤为明显，它们可使血压大幅下降，但既无抗血小板作用也无抗血栓形成作用。这表明降压活性的机制与抗血小板活性的机制不同。
