生长抑素对胃近端运动功能和内脏感觉的影响。
Effects of somatostatin on proximal gastric motor function and visceral perception.
作者信息
Mearadji B, Straathof J W, Biemond I, Lamers C B, Masclee A A
机构信息
Department of Gastroenterology-Hepatology, Leiden University Medical Center, The Netherlands.
出版信息
Aliment Pharmacol Ther. 1998 Nov;12(11):1163-9. doi: 10.1046/j.1365-2036.1998.00402.x.
BACKGROUND
Somatostatin affects gastrointestinal motility and secretion and visceral sensation, but little is known about its effects on the proximal stomach.
AIM
To evaluate the effects of somatostatin on proximal gastric motor function and perception of symptoms.
METHODS
Six healthy subjects participated in two experiments performed in random order during continuous intravenous infusion of saline or somatostatin (250 microg/h). Proximal gastric motor function was evaluated using a barostat. We performed pressure and volume distensions and a barostat procedure (minimal distending pressure + 2 mmHg). Symptoms were evaluated at regular intervals using visual analogue scales (VAS).
RESULTS
Neither minimal distending pressure nor gastric fundal tone were significantly different between somatostatin and saline. Pressure-volume curves during distensions were not influenced by somatostatin. However, phasic volume waves were significantly (P < 0.001) reduced by somatostatin, and somatostatin significantly (P < 0.05) reduced symptom perception of fullness and abdominal pressure during stepwise distensions.
背景
生长抑素影响胃肠动力、分泌及内脏感觉，但对胃近端的影响知之甚少。
目的
评估生长抑素对胃近端运动功能及症状感知的影响。
方法
6名健康受试者参与两项实验，在持续静脉输注生理盐水或生长抑素（250微克/小时）期间随机进行。使用压力调节器评估胃近端运动功能。我们进行了压力和容量扩张以及压力调节器程序（最小扩张压力 + 2 mmHg）。使用视觉模拟量表（VAS）定期评估症状。
结果
生长抑素和生理盐水之间的最小扩张压力及胃底张力均无显著差异。扩张期间的压力 - 容量曲线不受生长抑素影响。然而，生长抑素使相位性容量波显著减少（P < 0.001），并且在逐步扩张期间，生长抑素显著降低了饱腹感和腹部压力的症状感知（P < 0.05）。
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