Cunat L, Membre H, Marchal L, Chaussidon M, Burnel D
Laboratoire de Chimie Générale Appliquée à la Médecine, Faculté de Médecine, Université Henri Poincaré, Vandoeuvre les Nancy, France.
Biol Trace Elem Res. 1998 Summer;64(1-3):43-59. doi: 10.1007/BF02783324.
The modification of peristaltic activity in the presence of several metal ions has been investigated in the rat intestine by the isolated organ technique. The metals tested modify the intestinal movements: aluminum, chromium, and yttrium cause a decrease of amplitude, while iron showed no effect. By use of microscopic techniques, the presence of yttrium hydroxide was observed in the intestinal tissues. Iron also appears as a precipitate outside of the intestinal serosal, which may explain why iron did not modify the peristaltism. Chromium and aluminum were not apparent to microscope, despite being detected and quantified in the tissues by means of atomic emission spectrometer. We conclude that the trivalent ions of these elements may operate differently on the mechanisms of intestinal contractions: yttrium precipitates in intercellular spaces, iron precipitates outside the intestines, and chromium and aluminum remain in solution and are distributed homogeneously in the smooth intestinal muscle.
通过离体器官技术，研究了几种金属离子存在时大鼠肠道蠕动活动的变化。所测试的金属会改变肠道运动：铝、铬和钇会导致振幅减小，而铁则无影响。通过显微镜技术观察到肠道组织中存在氢氧化钇。铁也以沉淀物的形式出现在肠浆膜外，这可能解释了为什么铁不会改变蠕动。尽管通过原子发射光谱仪在组织中检测并定量了铬和铝，但在显微镜下它们并不明显。我们得出结论，这些元素的三价离子可能对肠道收缩机制有不同的作用：钇沉淀在细胞间隙中，铁沉淀在肠外，而铬和铝则保留在溶液中并均匀分布在肠道平滑肌中。
