Postexposure prophylaxis implementation issues: programmatic concerns in hospitals.

The administration of a human immunodeficiency virus (HIV) postexposure care program can be particularly difficult in complex medical centers that have multiple sites, diverse programs, and numerous types of patient interactions. The concern to optimize such programs is heightened if the institution cares for populations in which the prevalence of HIV positivity is high, as is the case in many urban healthcare facilities. This article discusses issues concerning implementation of a program of postexposure prophylaxis.