Liu T Z, Stern A, Morrow J D
Department of Medical Research, Yuan's General Hospital, Kaohsiung, Taiwan, ROC.
J Biomed Sci. 1998 Nov-Dec;5(6):415-20. doi: 10.1007/BF02255929.
The development of a specific, reliable and noninvasive method for measuring oxidative stress in humans is essential for establishing the role of free radicals in human diseases. Currently, accurate techniques to assess oxidant injury in vivo are extremely limited although a number of approaches are being investigated. Of these, the measurement of specific products of nonenzymatic lipid peroxidation, the F2-isoprostanes (F2-IsoPs), appears to be a more accurate marker of oxidative stress in vivo in humans than other available methods. The purpose of this brief review is to acquaint the reader with the IsoPs from a biochemical perspective and to provide information regarding the utility of quantifying these compounds as indicators of oxidant stress.
开发一种用于测量人体氧化应激的特异性、可靠且无创的方法，对于确定自由基在人类疾病中的作用至关重要。目前，尽管正在研究多种方法，但用于评估体内氧化剂损伤的准确技术极为有限。其中，非酶脂质过氧化的特定产物F2-异前列腺素（F2-IsoPs）的测量，似乎比其他现有方法更能准确地反映人体体内的氧化应激。本简要综述的目的是从生化角度让读者了解异前列腺素，并提供有关将这些化合物定量作为氧化应激指标的实用性的信息。
