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[食物条件性操作反射习得对大鼠脑内谷氨酸受体结合的影响]

[Effect of food conditioned operant reflex acquisition on the glutamate receptor binding in the rat brain].

作者信息

Karpova I V

机构信息

Pavlov St. Petersburg State Medical University, Russia.

出版信息

Ross Fiziol Zh Im I M Sechenova. 1998 Sep;84(9):913-9.

PMID:9845913
Abstract

Glutamate receptor binding in the striatum of fast-learning (FL) and dull (D) rats was significantly higher than in the control. In slow-learning (SL) rats, this parameter was lesser than in the FL or D animals and even lesser than in the control. In all the groups of trained rats, the glutamate receptor binding level was increased as compared with the control, whereas in the brain cortex it was decreased. The glutamate-dopaminergic interaction seems to be important as a basis of learning ability.

摘要

快速学习(FL)和迟钝(D)大鼠纹状体中的谷氨酸受体结合显著高于对照组。在慢学习(SL)大鼠中,该参数低于FL或D组动物,甚至低于对照组。在所有训练大鼠组中,与对照组相比,谷氨酸受体结合水平升高,而在大脑皮层中则降低。谷氨酸-多巴胺能相互作用似乎作为学习能力的基础很重要。

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