Kopala L C, Day C, Dillman B, Gardner D
Department of Psychiatry, Nova Scotia Hospital, Halifax, NS.
J Psychiatry Neurosci. 1998 Nov;23(5):305-8.
Deliberate drug overdose is a frequent occurrence in patients with schizophrenia. Typical antipsychotic medications can be lethal at doses 5 times the recommended therapeutic range. Clozapine, an atypical antipsychotic, can be toxic at doses 4 times a moderate dose. Little is known about the lethal effects of the novel antipsychotic risperidone, despite the fact that it is now one of the most widely prescribed antipsychotics in North America. To date, only 1 death attributable to risperidone overdose has been reported. The case presented here documents adverse cardiac effects in a 28-year-old man who intentionally ingested 24 mg of risperidone--4 times the recommended dose. A potential drug interaction with fluvoxamine and the role of active metabolites are discussed.
故意药物过量在精神分裂症患者中屡见不鲜。典型抗精神病药物在剂量达到推荐治疗范围5倍时可能致命。非典型抗精神病药物氯氮平，在剂量达到中等剂量4倍时可能有毒性。尽管新型抗精神病药物利培酮如今是北美处方量最广的药物之一，但关于其致死效应却知之甚少。迄今为止，仅报告过1例因过量服用利培酮导致死亡的病例。本文所呈现的病例记录了一名28岁男子故意摄入24毫克利培酮（推荐剂量的4倍）后出现的不良心脏效应。文中讨论了与氟伏沙明的潜在药物相互作用以及活性代谢物的作用。
