Martín Govantes J, Rafel Ribas E, Carballo Pérez A
An Esp Pediatr. 1976 Jul-Aug;9(4):447-52.
A case of systemic lupus erythematosus in a 3-year-old girl is presented. The diagnosis is based on the systemic involvement and repeated positivity for anti-DNA antibodies and L.E. phenomenon. A renal biopsy under optic and electron microscopy, disclosed diffuse glomerular cell proliferation and electron-dense deposits along the basal membrane. Increased basement membrane-like material is present between mesangial cells. Hematoxilinic bodies or virus-like inclusions were not found. Treatment with corticosteroids gave good results. A trial with antimalarial drugs had to be discontinued due to gastric intolerance and alopecia.
本文报告了一名3岁女童系统性红斑狼疮的病例。诊断基于全身受累以及抗DNA抗体和狼疮细胞现象反复呈阳性。光学显微镜和电子显微镜下的肾脏活检显示，肾小球弥漫性细胞增殖，沿基底膜有电子致密沉积物。系膜细胞之间存在增多的基底膜样物质。未发现苏木精小体或病毒样包涵体。使用皮质类固醇治疗效果良好。由于胃部不耐受和脱发，抗疟药试验不得不中止。
