Chippaux J P, Nkinin S W, Gardon-Wendel N, Ducorps M
ORSTOM, Centre Pasteur du Cameroun.
Bull Soc Pathol Exot. 1998;91(4):297-9.
This study concerns 112 patients of whom 104 were followed up. Microfilaricidal treatment of loaiasis is sometimes followed by severe adverse reactions. Using an immunodiffusion technique and the measure of microfilaraemia by calibrated thick smear, the authors show that the intensity of adverse reactions is proportional to the quantity of microfilariae eliminated by the treatment. The appearance of Loa loa antigens within three days following treatment was evident in 83% of the subjects. Five patients presenting the serious adverse reactions described belonged to this group. However, the precise cause of these adverse reactions, allergic or toxic, has not been demonstrated.
本研究涉及112例患者，其中104例接受了随访。罗阿丝虫病的微丝蚴杀灭治疗有时会伴有严重不良反应。作者采用免疫扩散技术并通过校准厚涂片测量微丝蚴血症，结果表明不良反应的强度与治疗清除的微丝蚴数量成正比。83%的受试者在治疗后三天内出现明显的罗阿丝虫抗原。出现所述严重不良反应的5例患者属于该组。然而，这些不良反应的确切原因，无论是过敏还是中毒，尚未得到证实。
