Saadé N E, Major S C, Jabbur S J, Atweh S F, Kanaan S A, Safieh-Garabedian B
Department of Human Morphology, Faculty of Medicine, American University of Beirut, Lebanon.
J Neuroimmunol. 1998 Nov 2;91(1-2):171-9. doi: 10.1016/s0165-5728(98)00176-3.
Intraplantar (5 ng) or intraperitoneal (50 ng) injections of thymulin, produced both thermal and mechanical hyperalgesia in rats. In this report, we show that ablation of capsaicin sensitive primary afferents (CSPA) can alter or abolish thymulin-induced hyperalgesia. Different groups of rats were subjected to either treatment with capsaicin or to surgical subdiaphragmatic vagotomy (SDV). Both capsaicin and SDV reduced significantly thymulin-induced hyperalgesia. On the other hand, these treatments elicited differential effects on the modulation by thymulin of the levels of nerve growth factor and interleukin 1beta. We conclude that the hyperalgesic effects of i.p. thymulin are mainly mediated through the CSPA fibers.
足底注射（5纳克）或腹腔注射（50纳克）胸腺素可在大鼠中产生热痛觉过敏和机械性痛觉过敏。在本报告中，我们表明辣椒素敏感的初级传入神经（CSPA）的消融可改变或消除胸腺素诱导的痛觉过敏。不同组的大鼠接受辣椒素治疗或手术膈下迷走神经切断术（SDV）。辣椒素和SDV均显著降低了胸腺素诱导的痛觉过敏。另一方面，这些治疗对胸腺素对神经生长因子和白细胞介素1β水平的调节产生了不同的影响。我们得出结论，腹腔注射胸腺素的痛觉过敏作用主要通过CSPA纤维介导。
