Blake J A, Richardson J E, Davisson M T, Eppig J T
The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
Nucleic Acids Res. 1999 Jan 1;27(1):95-8. doi: 10.1093/nar/27.1.95.
The Mouse Genome Database (MGD) focuses on the integration of mapping, homology, polymorphism and molecular data about the laboratory mouse. Detailed descriptions of genes including their chromosomal location, gene function, disease associations, mutant phenotypes, molecular polymorphisms and links to representative sequences including ESTs are integrated within MGD. The association of information from experiment to gene to genome requires careful coordination and implementation of standardized vocabularies, unique nomenclature constructions, and detailed information derived from multiple sources. This information is linked to other public databases that focus on additional information such as expression patterns, sequences, bibliographic details and large mapping panel data. Scientists participate in the curation of MGD data by generating the Chromosome Committee Reports, consulting on gene family nomenclature revisions, and providing descriptions of mouse strain characteristics and of new mutant phenotypes. MGD is accessible at http://www.informatics.jax.org
小鼠基因组数据库(MGD)专注于整合有关实验室小鼠的图谱、同源性、多态性和分子数据。包括基因的染色体定位、基因功能、疾病关联、突变体表型、分子多态性以及与包括ESTs在内的代表性序列的链接等基因的详细描述都整合在MGD中。从实验到基因再到基因组的信息关联需要仔细协调并实施标准化词汇、独特的命名结构以及来自多个来源的详细信息。这些信息与其他公共数据库相链接,这些数据库专注于诸如表达模式、序列、文献细节和大型图谱数据等额外信息。科学家们通过生成染色体委员会报告、就基因家族命名修订提供咨询以及提供小鼠品系特征和新突变体表型的描述来参与MGD数据的管理。可通过http://www.informatics.jax.org访问MGD