Danchin A
Ann Immunol (Paris). 1976 Sep-Oct;127(5):787-804.
A new selective theory for the specification of the antibody production is presented. It is grounded on the following postulates: (a) the antigen stimulus triggers the synthesis of antibodies having a wide variety of specificities in a given immunocompetent cell and its progeny; (b) only these antibodies having affinity for the antigen have their synthesis stabilized, and competition between the diverse syntheses will favor the antibodies having the highest affinity; (c) there existes a threshold synthesis such that when the production of an antibody becomes lower than the threshold, it will go to zero. As a consequence, one should observe, immediately after the antigen stimulus, the transient appearance of a large number of seemingly unspecific immunoglobulins, followed by specific antibodies. The apparent binding constant of these antibodies should also increase during the specification period. Besides, one should observe a small, but detectable amount of self antibodies during the early period of specification. Finally, in the presence of several antigens, one should find cells which appear to produce antibodies against several antigens during a transient period.
提出了一种关于抗体产生特异性的新选择理论。该理论基于以下假设：(a)抗原刺激引发给定免疫活性细胞及其后代合成具有多种特异性的抗体；(b)只有那些对抗原有亲和力的抗体其合成才会稳定下来，不同合成之间的竞争将有利于具有最高亲和力的抗体；(c)存在一个阈值合成，使得当一种抗体的产生低于阈值时，它将变为零。因此，人们应该观察到，在抗原刺激后立即出现大量看似非特异性的免疫球蛋白的短暂出现，随后是特异性抗体。在特异性形成期间，这些抗体的表观结合常数也应该增加。此外，在特异性形成的早期应该观察到少量但可检测到的自身抗体。最后，在存在几种抗原的情况下，应该发现一些细胞在短暂时期内似乎产生针对几种抗原的抗体。
