源自人类免疫缺陷病毒1型（HIV-1）gp120的C4-V3杂交肽溶液构象的核磁共振分析：与肽诱导的抗HIV中和抗体特异性的关系
Nuclear magnetic resonance analysis of solution conformations in C4-V3 hybrid peptides derived from human immunodeficiency virus (HIV) type 1 gp120: relation to specificity of peptide-induced anti-HIV neutralizing antibodies.
作者信息
Vu H M, Myers D, de Lorimier R, Matthews T J, Moody M A, Heinly C, Torres J V, Haynes B F, Spicer L
机构信息
Departments of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.
出版信息
J Virol. 1999 Jan;73(1):746-50. doi: 10.1128/JVI.73.1.746-750.1999.
Abstract
Immunogenic peptides containing epitopes of the gp120 C4 and V3 regions from human immunodeficiency virus strains MN and EV91 have been studied by nuclear magnetic resonance and molecular modeling and used as immunogens in rhesus monkeys. The results, combined with those for other peptides, suggest a correlation between solution conformation and immunologic cross-reactivity.
摘要
含有来自人类免疫缺陷病毒MN株和EV91株的gp120 C4和V3区域表位的免疫原性肽已通过核磁共振和分子建模进行了研究，并用作恒河猴的免疫原。这些结果与其他肽的结果相结合，表明溶液构象与免疫交叉反应性之间存在相关性。
相似文献
1
Nuclear magnetic resonance analysis of solution conformations in C4-V3 hybrid peptides derived from human immunodeficiency virus (HIV) type 1 gp120: relation to specificity of peptide-induced anti-HIV neutralizing antibodies.源自人类免疫缺陷病毒1型（HIV-1）gp120的C4-V3杂交肽溶液构象的核磁共振分析：与肽诱导的抗HIV中和抗体特异性的关系
J Virol. 1999 Jan;73(1):746-50. doi: 10.1128/JVI.73.1.746-750.1999.
2
Induction of antibodies in guinea pigs and rhesus monkeys against the human immunodeficiency virus type 1 envelope: neutralization of nonpathogenic and pathogenic primary isolate simian/human immunodeficiency virus strains.在豚鼠和恒河猴体内诱导针对1型人类免疫缺陷病毒包膜的抗体：对非致病性和致病性原代分离猿猴/人类免疫缺陷病毒株的中和作用。
J Virol. 2000 Jan;74(1):254-63. doi: 10.1128/jvi.74.1.254-263.2000.
3
Synthetic peptides containing T and B cell epitopes from human immunodeficiency virus envelope gp120 induce anti-HIV proliferative responses and high titers of neutralizing antibodies in rhesus monkeys.含有来自人类免疫缺陷病毒包膜糖蛋白120的T细胞和B细胞表位的合成肽，可在恒河猴中诱导抗HIV增殖反应和高滴度的中和抗体。
J Immunol. 1990 Oct 15;145(8):2677-85.
4
5
NMR-derived solution conformations of a hybrid synthetic peptide containing multiple epitopes of envelope protein gp120 from the RF strain of human immunodeficiency virus.源自核磁共振的一种包含人类免疫缺陷病毒RF株包膜蛋白gp120多个表位的杂交合成肽的溶液构象。
Biochemistry. 1994 Mar 1;33(8):2055-62. doi: 10.1021/bi00174a011.
6
Conformational preferences of a chimeric peptide HIV-1 immunogen from the C4-V3 domains of gp120 envelope protein of HIV-1 CAN0A based on solution NMR: comparison to a related immunogenic peptide from HIV-1 RF.基于溶液核磁共振的HIV-1 CAN0A包膜蛋白gp120的C4-V3结构域嵌合肽HIV-1免疫原的构象偏好：与HIV-1 RF的相关免疫原性肽的比较
Biochemistry. 1996 Apr 23;35(16):5158-65. doi: 10.1021/bi952665x.
7
Conformation of the principal neutralizing determinant of human immunodeficiency virus type 1 in complex with an anti-gp120 virus neutralizing antibody studied by two-dimensional nuclear magnetic resonance difference spectroscopy.利用二维核磁共振差异光谱法研究1型人类免疫缺陷病毒主要中和决定簇与抗gp120病毒中和抗体复合物的构象。
Biochemistry. 1997 Jul 15;36(28):8619-27. doi: 10.1021/bi970520f.
8
The effect of low-profile serine substitutions in the V3 loop of HIV-1 gp120 IIIB/LAI on the immunogenicity of the envelope protein.HIV-1 gp120 IIIB/LAI的V3环中低轮廓丝氨酸取代对包膜蛋白免疫原性的影响。
Virology. 1998 Nov 10;251(1):59-70. doi: 10.1006/viro.1998.9392.
9
Immunological reactivity of a human immunodeficiency virus type I derived peptide representing a consensus sequence of the GP120 major neutralizing region V3.一种代表HIV-1型病毒糖蛋白120主要中和区域V3共有序列的衍生肽的免疫反应性
Arch Virol. 1992;127(1-4):139-52. doi: 10.1007/BF01309580.
10
Variant-specific monoclonal and group-specific polyclonal human immunodeficiency virus type 1 neutralizing antibodies raised with synthetic peptides from the gp120 third variable domain.用来自gp120第三可变区的合成肽产生的1型人类免疫缺陷病毒特异性单克隆抗体和组特异性多克隆中和抗体。
J Virol. 1992 Mar;66(3):1823-31. doi: 10.1128/JVI.66.3.1823-1831.1992.
引用本文的文献
1
Crystal structures of human immunodeficiency virus type 1 (HIV-1) neutralizing antibody 2219 in complex with three different V3 peptides reveal a new binding mode for HIV-1 cross-reactivity.1型人类免疫缺陷病毒（HIV-1）中和抗体2219与三种不同V3肽复合物的晶体结构揭示了HIV-1交叉反应性的一种新结合模式。
J Virol. 2006 Jun;80(12):6093-105. doi: 10.1128/JVI.00205-06.
2
Probing hydrogen bonds in the antibody-bound HIV-1 gp120 V3 loop by solid state NMR REDOR measurements.通过固态核磁共振REDOR测量探究抗体结合的HIV-1 gp120 V3环中的氢键。
J Biomol NMR. 2000 Apr;16(4):313-27. doi: 10.1023/a:1008343623240.
3
Induction of antibodies in guinea pigs and rhesus monkeys against the human immunodeficiency virus type 1 envelope: neutralization of nonpathogenic and pathogenic primary isolate simian/human immunodeficiency virus strains.在豚鼠和恒河猴体内诱导针对1型人类免疫缺陷病毒包膜的抗体：对非致病性和致病性原代分离猿猴/人类免疫缺陷病毒株的中和作用。
J Virol. 2000 Jan;74(1):254-63. doi: 10.1128/jvi.74.1.254-263.2000.
本文引用的文献
1
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody.与CD4受体及一种中和性人抗体结合的HIV gp120包膜糖蛋白的结构
Nature. 1998 Jun 18;393(6686):648-59. doi: 10.1038/31405.
2
A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding.一种参与趋化因子受体结合的保守HIV gp120糖蛋白结构。
Science. 1998 Jun 19;280(5371):1949-53. doi: 10.1126/science.280.5371.1949.
3
Identification of a synthetic peptide that mimics an HIV glycoprotein 120 envelope conformational determinant exposed following ligation of glycoprotein 120 by CD4.鉴定一种合成肽，该肽模拟了在CD4与糖蛋白120连接后暴露的HIV糖蛋白120包膜构象决定簇。
AIDS Res Hum Retroviruses. 1997 May 20;13(8):657-64. doi: 10.1089/aid.1997.13.657.
4
The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.β趋化因子受体CCR3和CCR5促进原发性HIV-1分离株的感染。
Cell. 1996 Jun 28;85(7):1135-48. doi: 10.1016/s0092-8674(00)81313-6.
5
Conformational features of a synthetic cyclic peptide corresponding to the complete V3 loop of the RF HIV-1 strain in water and water/trifluoroethanol solutions.一种与RF HIV-1毒株完整V3环对应的合成环肽在水和水/三氟乙醇溶液中的构象特征。
Eur J Biochem. 1996 Feb 15;236(1):100-8. doi: 10.1111/j.1432-1033.1996.00100.x.
6
Conformational preferences of a chimeric peptide HIV-1 immunogen from the C4-V3 domains of gp120 envelope protein of HIV-1 CAN0A based on solution NMR: comparison to a related immunogenic peptide from HIV-1 RF.基于溶液核磁共振的HIV-1 CAN0A包膜蛋白gp120的C4-V3结构域嵌合肽HIV-1免疫原的构象偏好：与HIV-1 RF的相关免疫原性肽的比较
Biochemistry. 1996 Apr 23;35(16):5158-65. doi: 10.1021/bi952665x.
7
8
Crystal structure of a human immunodeficiency virus type 1 neutralizing antibody, 50.1, in complex with its V3 loop peptide antigen.1型人类免疫缺陷病毒中和抗体50.1与其V3环肽抗原复合物的晶体结构。
Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6325-9. doi: 10.1073/pnas.90.13.6325.
9
Local and global structural properties of the HIV-MN V3 loop.
J Biol Chem. 1995 Feb 3;270(5):2224-32. doi: 10.1074/jbc.270.5.2224.
10
The antigenic identity of peptide-MHC complexes: a comparison of the conformations of five viral peptides presented by HLA-A2.肽-MHC复合物的抗原同一性：对由HLA-A2呈递的五种病毒肽构象的比较。
Cell. 1993 Nov 19;75(4):693-708. doi: 10.1016/0092-8674(93)90490-h.
Zotero 插件