Fagan T, Woodland Hastings J, Morse D
Department of Molecular & Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138-2020, USA.
J Mol Evol. 1998 Dec;47(6):633-9. doi: 10.1007/pl00006420.
Sequence analysis of two nuclear-encoded glyceraldehyde-3-phosphate dehydrogenase (GAPDH) genes isolated from the dinoflagellate Gonyaulax polyedra distinguishes them as cytosolic and chloroplastic forms of the enzyme. Distance analysis of the cytosolic sequence shows the Gonyaulax gene branching early within the cytosolic clade, consistent with other analyses. However, the plastid sequence forms a monophyletic group with the plastid isoforms of cryptomonads, within an otherwise cytosolic clade, distinct from all other plastid GAPDHs. This is attributed to lateral gene transfer from an ancestral cryptomonad to a dinoflagellate, providing the first example of genetic exchange accompanying symbiotic associations between the two, which are common in present day cells.
从多甲藻（Gonyaulax polyedra）中分离出的两个核编码甘油醛-3-磷酸脱氢酶（GAPDH）基因的序列分析，将它们区分为该酶的胞质型和叶绿体型。对胞质序列的距离分析表明，多甲藻基因在胞质进化枝中早期分支，这与其他分析结果一致。然而，质体序列与隐藻的质体异构体形成一个单系群，位于一个其他部分为胞质的进化枝内，与所有其他质体GAPDH不同。这归因于从祖先隐藻到甲藻的横向基因转移，这是两者共生关联伴随的基因交换的首个例子，这种共生关联在当今细胞中很常见。
