Kuge Y, Akai N, Tamura K, Yamada M, Tanizaki N, Hashimoto T, Imanishi M, Shiomi M, Ishida Y, Hashimoto N
Sumitomo Heavy Industries, Ltd.
Kaku Igaku. 1998 Oct;35(8):733-40.
ProASSIST, a semi-automatic ROI (region of interest) setting system for human brain PET images, has been modified for use with the canine brain, and the performance of the obtained system was evaluated by comparing the operational simplicity for ROI setting and the consistency of ROI values obtained with those by a conventional manual procedure. Namely, we created segment maps for the canine brain by making reference to the coronal section atlas of the canine brain by Lim et al., and incorporated them into the ProASSIST system. For the performance test, CBF (cerebral blood flow) and CMRglc (cerebral metabolic rate in glucose) images in dogs with or without focal cerebral ischemia were used. In ProASSIST, brain contours were defined semiautomatically. In the ROI analysis of the test image, manual modification of the contour was necessary in half cases examined (8/16). However, the operation was rather simple so that the operation time per one brain section was significantly shorter than that in the manual operation. The ROI values determined by the system were comparable with those by the manual procedure, confirming the applicability of the system to these animal studies. The use of the system like the present one would also merit the more objective data acquisition for the quantitative ROI analysis, because no manual procedure except for some specifications of the anatomical features is required for ROI setting.
ProASSIST是一种用于人类脑PET图像的半自动感兴趣区（ROI）设置系统，现已针对犬脑进行了修改，并通过比较ROI设置的操作简便性以及与传统手动程序获得的ROI值的一致性，对所得系统的性能进行了评估。具体而言，我们参考Lim等人的犬脑冠状切面图谱创建了犬脑的分割图，并将其纳入ProASSIST系统。对于性能测试，使用了患有或未患有局灶性脑缺血的犬的脑血流量（CBF）和脑葡萄糖代谢率（CMRglc）图像。在ProASSIST中，脑轮廓是半自动定义的。在测试图像的ROI分析中，在所检查的一半病例（8/16）中需要手动修改轮廓。然而，操作相当简单，以至于每个脑切片的操作时间明显短于手动操作。该系统确定的ROI值与手动程序确定的值相当，证实了该系统在这些动物研究中的适用性。像本系统这样的系统的使用对于定量ROI分析而言，在获取更客观的数据方面也具有优势，因为除了一些解剖特征的指定外，ROI设置不需要手动程序。
