庆大霉素和头孢菌素引起的血尿素氮升高。
Gentamicin- and cephalothin-associated rises in blood urea nitrogen.
作者信息
Fanning W L, Gump D, Jick H
出版信息
Antimicrob Agents Chemother. 1976 Jul;10(1):80-2. doi: 10.1128/AAC.10.1.80.
Abstract
Standardized rates of drug-attributed rises in blood urea nitrogen were 8.6%, 2.9%, and 9.3%, respectively, in patients receiving gentamicin alone, cephalothin alone, and both drugs together. These results provide evidence against a substantial synergism between the two drugs in the production of impaired renal function.
摘要
单独接受庆大霉素治疗、单独接受头孢噻吩治疗以及同时接受两种药物治疗的患者中，药物所致血尿素氮升高的标准化发生率分别为8.6%、2.9%和9.3%。这些结果提供了证据，表明这两种药物在导致肾功能损害方面不存在显著的协同作用。
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本文引用的文献
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JAMA. 1970 Aug 31;213(9):1455-60.
2
Declining renal function associated with administration of cephalothin.与头孢噻吩给药相关的肾功能下降。
South Med J. 1970 Apr;63(4):426-8. doi: 10.1097/00007611-197004000-00020.
3
Relative nephrotoxicity of cephalosporin antibiotics in an animal model.头孢菌素类抗生素在动物模型中的相对肾毒性
Can Med Assoc J. 1972 Sep 9;107(5):414-6.
4
Acute renal failure associated with combined gentamicin and cephalothin therapy.庆大霉素与头孢噻吩联合治疗相关的急性肾衰竭
Br Med J. 1973 May 19;2(5863):396-7. doi: 10.1136/bmj.2.5863.396.
5
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