庆大霉素与头孢噻吩联合治疗相关的急性肾衰竭
Acute renal failure associated with combined gentamicin and cephalothin therapy.
作者信息
Fillastre J P, Laumonier R, Humbert G, Dubois D, Metayer J, Delpech A, Leroy J, Robert M
出版信息
Br Med J. 1973 May 19;2(5863):396-7. doi: 10.1136/bmj.2.5863.396.
Abstract
Three patients with normal renal function developed acute renal failure between the ninth and twenty-seventh days of combined gentamicin and cephalothin therapy. The dose of gentamicin (4-6 mg/kg/day) was in the normal range, but that of cephalothin (180 mg/kg/day) was abnormally high. The nephropathy was of the tubular-interstitial type and the clinical picture similar to that seen in acute drug-induced nephropathies. Frusemide was given only after the onset of renal failure. In these three patients the high intravenous doses of cephalothin combined with gentamicin were probably nephrotoxic.
摘要
三名肾功能正常的患者在庆大霉素与头孢噻吩联合治疗的第9天至第27天之间发生了急性肾衰竭。庆大霉素的剂量（4 - 6毫克/千克/天）在正常范围内，但头孢噻吩的剂量（180毫克/千克/天）异常高。肾病为肾小管间质性类型，临床表现与急性药物性肾病所见相似。速尿仅在肾衰竭发作后才给予。在这三名患者中，高静脉剂量的头孢噻吩与庆大霉素联合使用可能具有肾毒性。
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