Schmidt K G, von Rückmann A, Klingmüller V, Becker R, Pillunat L E, Mittag T W
Univ.-Augenklinik, Giessen.
Klin Monbl Augenheilkd. 1998 Oct;213(4):241-4. doi: 10.1055/s-2008-1034980.
The mechanism for the control of choroidal perfusion is unclear. The present study was designed to investigate for the effect of standardized alteration of systemic perfusion parameters on choroidal hemodynamics in healthy volunteers.
Intraocular pressure (IOP; German abbreviation: IOD), Ocular Pulse Amplitude (OPA), systemic blood pressure, and pulse rate were measured, and ocular perfusion pressure was calculated in 14 otherwise non-smoking, healthy volunteers prior to and following exercise and smoking.
Exercise significantly (sig., p < 0.05) increased pulse rate, systolic blood pressure and ocular perfusion pressure, while it sig. (p < 0.05) reduced IOP and diastolic blood pressure. However OPA was not sig. (p > 0.1) affected by changes in these parameters. Smoking sig. (p < 0.05) increased systolic blood pressure, diastolic blood pressure, pulse rate, and ocular perfusion pressure but did not sig. (p > 0.09) alter OPA.
Despite affecting ocular and systemic perfusion parameters, exercise and smoking did not alter OPA, suggesting functional isolation i.e. autoregulation of the choroidal and/or ophthalmic artery circulation.
脉络膜灌注的控制机制尚不清楚。本研究旨在调查全身灌注参数的标准化改变对健康志愿者脉络膜血流动力学的影响。
在14名不吸烟的健康志愿者运动和吸烟前后，测量眼内压（IOP；德语缩写：IOD）、眼脉搏振幅（OPA）、全身血压和脉搏率，并计算眼灌注压。
运动显著（p < 0.05）增加脉搏率、收缩压和眼灌注压，同时显著（p < 0.05）降低眼内压和舒张压。然而，OPA不受这些参数变化的显著（p > 0.1）影响。吸烟显著（p < 0.05）增加收缩压、舒张压、脉搏率和眼灌注压，但未显著（p > 0.09）改变OPA。
尽管运动和吸烟影响眼和全身灌注参数，但并未改变OPA，提示脉络膜和/或眼动脉循环存在功能隔离，即自动调节。
