Schmidt K G, von Rückmann A, Klingmüller V, Pillunat L E, Mittag T W
Univ.-Augenklinik, Giessen.
Klin Monbl Augenheilkd. 1998 Dec;213(6):347-50. doi: 10.1055/s-2008-1035000.
Choroidal autoregulation is discussed controversially. The present study was designed to investigate for the effect of standardized manipulation of local perfusion parameters on choroidal hemodynamics in cynomolgus monkey eyes with lasersurgically induced glaucoma (CMG; German abbreviation: RA-LHDG).
CMG unilaterally received 2-3 laser treatments so as to develop the lasered-eye glaucoma model. Intraocular pressure (IOP; German abbreviation: IOD) and Ocular Pulse Amplitude (OPA) were measured and Peak Pulse Blood Volume (PPBV; German abbreviation: PGBV) was determined.
In CMG PPBV was not significantly (sig., p > 0.05) altered in laser-treated eyes--despite a sig. (p < 0.05) increase in IOP. Untreated contralateral control eyes of monkeys with an IOP-increase > 5 mm Hg in laser-treated eyes showed a sig. (p < 0.05) increase in PPBV.
Unchanged PPBV in laser-treated eyes of CMG and an increase in PPBV in control eyes point at a bilateral autoregulatory compensatory mechanism, which is more manifest in eyes with IOPs in the normal range.
脉络膜自身调节存在争议。本研究旨在探讨局部灌注参数的标准化操作对激光诱导青光眼（CMG；德语缩写：RA-LHDG）的食蟹猴眼脉络膜血流动力学的影响。
CMG单侧接受2 - 3次激光治疗以建立激光眼青光眼模型。测量眼内压（IOP；德语缩写：IOD）和眼脉搏振幅（OPA），并测定峰值脉搏血容量（PPBV；德语缩写：PGBV）。
在CMG中，尽管激光治疗眼的IOP显著（p < 0.05）升高，但激光治疗眼的PPBV没有显著（sig.，p > 0.05）改变。激光治疗眼的IOP升高> 5 mmHg的猴子的未治疗对侧对照眼的PPBV显著（p < 0.05）升高。
CMG激光治疗眼的PPBV不变，对照眼的PPBV升高表明存在双侧自身调节补偿机制，这在眼压处于正常范围的眼中更为明显。
