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A highly conservative, cyclically permuted, non-homologous exchange among three unrelated DNA sequences in bleomycin-treated CHO cells.

作者信息

Povirk L F

机构信息

Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA.

出版信息

Int J Radiat Biol. 1998 Nov;74(5):561-4. doi: 10.1080/095530098141131.

DOI:10.1080/095530098141131
PMID:9848274
Abstract

Molecular analysis of a bleomycin-induced rearrangement of the aprt gene in CHO cells revealed that it consisted of a nearly perfect three-way exchange among non-homologous sequences, consistent with a mechanism involving cyclically permuted misjoining of the six ends of three double-strand breaks.

摘要

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引用本文的文献

1
Gene rearrangements induced by the DNA double-strand cleaving agent neocarzinostatin: conservative non-homologous reciprocal exchanges in an otherwise stable genome.由DNA双链切割剂新制癌菌素诱导的基因重排：在其他方面稳定的基因组中的保守非同源相互交换。
Nucleic Acids Res. 2002 Jun 15;30(12):2639-46. doi: 10.1093/nar/gkf369.