Coudron P E, Stratton C W
Pathology and Laboratory Medicine Service, McGuire Veterans Affairs Medical Center, Richmond, VA 23249-0001, USA.
J Antimicrob Chemother. 1998 Nov;42(5):657-60. doi: 10.1093/jac/42.5.657.
Increasing metronidazole resistance suggests the need for alternative antibiotics for combination therapy of Helicobacter pylori infections. We evaluated a metronidazole-resistant and a clarithromycin-resistant strain of H. pylori under stationary growth phase conditions that favoured physiological conditions in order to determine if nitrofurantoin might be a suitable alternative for metronidazole in combination therapy. The results demonstrated that the triple combination of bismuth, tetracycline and nitrofurantoin achieved greater bactericidal activity against these two strains than did the combination of bismuth, tetracycline and metronidazole. These results suggest that further evaluation is warranted.
甲硝唑耐药性的增加表明，在幽门螺杆菌感染的联合治疗中需要使用替代抗生素。我们在有利于生理条件的稳定生长期条件下，评估了一株甲硝唑耐药和一株克拉霉素耐药的幽门螺杆菌菌株，以确定呋喃妥因是否可能是联合治疗中甲硝唑的合适替代品。结果表明，铋剂、四环素和呋喃妥因的三联组合对这两种菌株的杀菌活性比铋剂、四环素和甲硝唑的组合更强。这些结果表明有必要进行进一步评估。
