Suneja A, Agarwal N, Misra K
Department of Gynaecology and Obstetrics, University College of Medical Sciences, Guru Teg Bahadur Hospital, Delhi, India.
Indian J Cancer. 1998 Jun;35(2):81-7.
Magnified Chemiluminescent Examination (MCE) or speculoscopy is a new visual method for detection of cervical neoplasia. It utilizes low magnification and a special "blue-white" chemiluminescent light. The study includes 125 women with unhealthy cervix who were subjected to magnified examination with projected incandescent light (PIL) and chemiluminescent light (MCE). This was followed by colposcopy and directed biopsy from acetowhite areas. Of all 125 subjects, 20 patients showed cervical neoplasia of varying degree on histopathology. MCE could detect 18/20 neoplasias while PIL detected 11/20 cases. Sensitivity of MCE (90%) was significantly superior (P < 0.05) to PIL (55%) in detecting cervical neoplasia. Colposcopy, as compared to MCE, is better than speculoscopy as it facilitates grading of lesions due to higher magnification but antecedent MCE detected the acetowhitening in majority of patients (32/43). However, tendency to "overall" acetowhite lesions was significantly less during MCE when compared with colposcopy. Thus, MCE is a new diagnostic tool which is better than routine incandescent light examination and correlates well with colposcopy.
放大化学发光检查（MCE）或直视镜检查是一种用于检测宫颈肿瘤的新视觉方法。它利用低倍放大和特殊的“蓝白色”化学发光。该研究纳入了125名宫颈不健康的女性，她们接受了投射白炽灯（PIL）和化学发光（MCE）的放大检查。随后进行阴道镜检查，并从醋酸白色区域进行定向活检。在所有125名受试者中，20例患者在组织病理学上显示出不同程度的宫颈肿瘤。MCE能检测出18/20例肿瘤，而PIL检测出11/20例。在检测宫颈肿瘤方面，MCE的灵敏度（90%）显著优于PIL（55%）（P<0.05）。与MCE相比，阴道镜检查由于放大倍数更高，更有利于病变分级，但先行的MCE在大多数患者（32/43）中检测到了醋酸白色改变。然而，与阴道镜检查相比，MCE期间“整体”醋酸白色病变的倾向明显更低。因此，MCE是一种新的诊断工具，优于常规白炽灯检查，且与阴道镜检查相关性良好。
