Goldman L I, Clark W H, Bernardino E A, Ainsworth A M
Ann Surg. 1976 Nov;184(5):537-40. doi: 10.1097/00000658-197611000-00002.
Since 1971, a prospective treatment regimen for primary cutaneous malignant melanoma performed by a single clinician has revealed the following early observations: 1) A significantly higher number of females with level II disease; 2) No recurrences or metastases to date in 29 patients with level II lesions treated by appropriate surgery; 3) The apparent clinical predictability of lymph node metastases in the group microstaged at level III. 4) An inability to predict lymph node metastases (or their delayed development) in patients with level IV disease; 5) A correlation between lymph node metastases and the development of disseminated disease.
自1971年以来，由一位临床医生实施的原发性皮肤恶性黑色素瘤前瞻性治疗方案得出了以下早期观察结果：1）II级疾病的女性患者数量显著更多；2）29例接受适当手术治疗的II级病变患者至今无复发或转移；3）III级微分期组中淋巴结转移具有明显的临床可预测性；4）IV级疾病患者无法预测淋巴结转移（或其延迟发生）；5）淋巴结转移与播散性疾病的发生之间存在关联。
