Kolb R, Gogolák G, Huck S, Jaschek I, Stumpf C
Arch Int Pharmacodyn Ther. 1976 Jul;222(1):149-56.
The electrocortical activity and the antibiotic concentration in serum and CSF were investigated in rabbits after i.v. administration of benzylpenicillin, ampicillin and oxacillin. In contrast to ampicillin and oxacillin, benzylpenicillin induced a pronounced epileptogenic activity. The different epileptogenic activity of the three penicillins cannot be explained by the difference in the CSF level of these agents only. The intensity of the epileptogenic activity and the CSF level after benzylpenicillin administration were markedly influenced by the experimental procedure in that curarized animals exhibited both higher CSF levels and more intense seizure activities than non-curarized animals. Factors are discussed which may be responsible for the different neurotoxic potency of the three penicillins and for the dependence of the benzylpenicillin-induced seizure intensity on the experimental procedure.
静脉注射苄青霉素、氨苄青霉素和苯唑西林后，对家兔的皮质电活动以及血清和脑脊液中的抗生素浓度进行了研究。与氨苄青霉素和苯唑西林不同，苄青霉素可诱发明显的致痫活性。这三种青霉素不同的致痫活性不能仅用这些药物在脑脊液中的水平差异来解释。苄青霉素给药后致痫活性的强度和脑脊液水平受到实验操作的显著影响，因为箭毒化的动物比未箭毒化的动物表现出更高的脑脊液水平和更强烈的癫痫活动。文中讨论了可能导致这三种青霉素神经毒性效力不同以及苄青霉素诱发癫痫强度依赖于实验操作的因素。
