多囊卵巢综合征中单核白细胞上的糖皮质激素受体。
Glucocorticoid receptors on mononuclear leukocytes in polycystic ovary syndrome.
作者信息
Güven M, Açbay O, Sultuybek G
机构信息
Department of Medical Biology, Cerrahpaşa Medical Faculty, Istanbul University, Turkey.
出版信息
Int J Gynaecol Obstet. 1998 Oct;63(1):33-7. doi: 10.1016/s0020-7292(98)00126-x.
OBJECTIVE
Many studies have suggested that there is a possible hormonal dysregulation of hypothalamic-pituitary-adrenal (HPA) axis and an increased cortisol clearance in patients with polycystic ovary syndrome (PCOS). Therefore in this study, we have examined the role of glucocorticoid receptor/s (GR) characteristics in the developing of these abnormalities in patients with PCOS.
METHOD
For this purpose, the number and affinity of GR in peripheral mononuclear leukocytes (MNL) of 10 patients with PCOS and 10 healthy women (controls) were determined.
RESULTS
There were no significant differences in the number (6500+/-1001 sites/cell and 6352+/-1697 sites/cell, respectively; P > 0.05) and affinity (3.93+/-0.89 nM and 4.49+/-0.71 nM, respectively; P > 0.05) of GR between the PCOS patients and the controls.
CONCLUSIONS
These results suggest that the alterations in the HPA axis and in the cortisol metabolism observed in PCOS are not related to GR deficiency.
目的
许多研究表明，多囊卵巢综合征（PCOS）患者可能存在下丘脑 - 垂体 - 肾上腺（HPA）轴激素调节异常以及皮质醇清除率增加。因此，在本研究中，我们研究了糖皮质激素受体（GR）特征在PCOS患者这些异常情况发生发展中的作用。
方法
为此，测定了10例PCOS患者和10名健康女性（对照组）外周血单个核白细胞（MNL）中GR的数量和亲和力。
结果
PCOS患者与对照组之间GR的数量（分别为6500±1001位点/细胞和6352±1697位点/细胞；P>0.05）和亲和力（分别为3.93±0.89 nM和4.49±0.71 nM；P>0.05）无显著差异。
结论
这些结果表明，PCOS患者中观察到的HPA轴和皮质醇代谢改变与GR缺乏无关。
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