Miller K, Richardson D A, Siegel S W, Karram M M, Blackwood N B, Sand P K
Department of Obstetrics and Gynecology, University of Utah, Salt Lake City 84132, USA.
Int Urogynecol J Pelvic Floor Dysfunct. 1998;9(5):265-70. doi: 10.1007/BF01901503.
This study sought to determine the characteristics of women in whom pelvic floor electrical stimulation will reduce stress urinary incontinence. It also evaluates how long electrical stimulation should be used before significant improvements are seen in clinical outcomes. Subjects with genuine stress incontinence were enrolled into a multicenter non-randomized trial. They used electrical stimulation for 15 minutes twice daily or every other day for 20 weeks. At the end of 20 weeks, those with a 50% reduction in leakage episodes on voiding diary ('responders') were compared with those who did not show a 50% reduction ('non-responders'). Thirty-one subjects were enrolled and 28 completed the study. After the treatment period, 19 subjects were defined as responders and 9 as non-responders. There were no significant differences between the two groups in baseline demographics (e.g. age, parity, largest birth weight etc.) other than body mass index (greater in nonresponders). Significant subjective and objective improvements were noted among responders by 10 and 14 weeks, respectively. Compliance was higher in responders during weeks 12-15 of the study (P=0.05). It was concluded that a minimum of 14 weeks of pelvic floor stimulation was necessary before significant objective improvements were seen. Body mass index and patient compliance may affect success.
本研究旨在确定盆底电刺激可减轻压力性尿失禁的女性特征。它还评估在临床结果出现显著改善之前，电刺激应使用多长时间。真性压力性尿失禁患者被纳入一项多中心非随机试验。他们每天两次或隔天使用电刺激15分钟，持续20周。在20周结束时，将排尿日记中漏尿次数减少50%的患者（“反应者”）与未减少50%的患者（“无反应者”）进行比较。共招募了31名受试者，28名完成了研究。治疗期结束后，19名受试者被定义为反应者，9名被定义为无反应者。除体重指数外（无反应者更高），两组在基线人口统计学特征（如年龄、产次、最大出生体重等）方面无显著差异。反应者在第10周和第14周时分别出现了显著的主观和客观改善。在研究的第12 - 15周，反应者的依从性更高（P = 0.05）。得出的结论是，在出现显著的客观改善之前，至少需要14周的盆底刺激。体重指数和患者依从性可能会影响治疗效果。
