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一氧化氮诱导氧合血红蛋白氧化过程中一种中间过氧亚硝酸根复合物的动力学和光谱表征

Kinetic and spectroscopic characterization of an intermediate peroxynitrite complex in the nitrogen monoxide induced oxidation of oxyhemoglobin.

作者信息

Herold S

机构信息

Laboratorium für Anorganische Chemie, Eidgenössische Technische Hochschule, Zürich, Switzerland.

出版信息

FEBS Lett. 1998 Nov 13;439(1-2):85-8. doi: 10.1016/s0014-5793(98)01345-3.

DOI:10.1016/s0014-5793(98)01345-3
PMID:9849883
Abstract

Stopped-flow spectroscopy studies of the nitrogen monoxide mediated oxidation of oxyhemoglobin in the pH range 5-10.5 show that an intermediate can be characterized at alkaline pH. The rate of decay of this species to methemoglobin increases significantly with decreasing pH such that it does not accumulate in quantities large enough to be observed under neutral or acidic conditions. Kinetic and spectroscopic properties of this intermediate support its assignment as a methemoglobin peroxynitrite complex.

摘要

在pH值为5 - 10.5范围内，对一氧化氮介导的氧合血红蛋白氧化进行的停流光谱研究表明，在碱性pH条件下可对一种中间体进行表征。随着pH值降低，该物种向高铁血红蛋白衰变的速率显著增加，以至于在中性或酸性条件下，它不会积累到足以被观测到的量。该中间体的动力学和光谱性质支持将其归属为高铁血红蛋白过氧亚硝酸盐复合物。

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