Tyers G F, Brownlee R R, Hughes H C, Manley N J, Gorman I N, Waldhausen J A
Arch Surg. 1976 Nov;111(11):1231-4. doi: 10.1001/archsurg.1976.01360290065009.
Since 1967, three series of rechargeable single-cell silver-mercuric oxide-zinc pacemakers have been implanted in dogs with complete heart block. The five nonhermetic units in series 1 failed after less than or equal to 18 months, primarily due to prototype cell deficiencies, although one cell functioned for eight years. The six units in series II contained improved cells, but failed due to gradual transepoxy fluid absorption after less than or equal to 31 months. All rechargeable cells were salvaged and dried, and, seven years after their manufacture, they continue to power pacing circuits. Series III now totals 20 doubly hermetically sealed units, tested for up to three years (total more than 300 months or 26 years), with no pacemaker failures. Accelerated tests indicate a minimum life of more than 50 years. A clinical trial is in progress.
自1967年以来,已将三个系列的可充电单节银汞氧化物锌起搏器植入患有完全性心脏传导阻滞的犬体内。系列1中的五个非密封装置在不到或等于18个月后失效,主要是由于原型电池存在缺陷,尽管有一个电池工作了八年。系列II中的六个装置包含改进后的电池,但在不到或等于31个月后,由于环氧树脂逐渐吸收液体而失效。所有可充电电池都被打捞出来并干燥,在制造七年后,它们仍继续为起搏电路供电。系列III目前共有20个双重密封装置,经过长达三年(总计超过300个月或26年)的测试,没有起搏器出现故障。加速测试表明其最短寿命超过50年。一项临床试验正在进行中。