Shubnikova E A, Pododina L S, Sukhova G K
Arkh Anat Gistol Embriol. 1976 Aug;71(8):33-9.
Cytological changes in the submaxillary glands of rat embryos of the 14th-21st days of the intrauterine development and of 7-day-old rats were studied electron microscopically. The cytoplasm of the salivary gland primordium cells of the 14-day embryo was found to possess multiple polysomes, the canals of the granular cytoplasmic network (GCN) being solitary. The latter elongated in the process of embryonic development, and later predominant development of GCN was observed in basal portions of the acinar cells. At early stages of the gland development the GCN was often observed to approximate mitochindria. The laminar complex in the course of embryonic development enlarges its size and at later stages it has a well differentiated appearance in the acinar cells. Secretory inclusions make their appearance in the forming cells of acinuses long before birth, the composition of the embryo gland secretion being somewhat different from that of adult animals. Differentiation of acinuses and striated parts of the salivary tubules is well pronounced in the embryonic period while no signs of appearance of granular portions of the salivary tubules are observed both in light and electron microscopy either in embryos or in 1-week-old rats.
对子宫内发育第14至21天的大鼠胚胎以及7日龄大鼠的颌下腺进行了电子显微镜下的细胞学变化研究。发现14天胚胎唾液腺原基细胞的细胞质中有多个多核糖体，颗粒状细胞质网络（GCN）的管道是单个的。后者在胚胎发育过程中伸长，随后在腺泡细胞基部观察到GCN的主要发育。在腺体发育的早期阶段，经常观察到GCN靠近线粒体。层状复合体在胚胎发育过程中尺寸增大，在后期阶段，它在腺泡细胞中有分化良好的外观。分泌性内含物在出生前很久就在腺泡的形成细胞中出现，胚胎腺体分泌物的组成与成年动物的有所不同。在胚胎期，腺泡和唾液小管横纹部分的分化很明显，而在胚胎或1周龄大鼠中，无论是在光学显微镜还是电子显微镜下，都未观察到唾液小管颗粒部分出现的迹象。
