Igbokwe I O, Isa S, Aliyu U K, Hamza H G, Egbe-Nwiyi T
Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Maiduguri, Nigeria.
Vet Res. 1998 Nov-Dec;29(6):573-8.
Twenty rats were made diabetic by treatment with alloxan monohydrate (10% solution, 100 mg/kg body weight). Ten diabetic and ten non-diabetic rats were intraperitoneally infected with the same infective doses of Trypanosoma brucei brucei (Lafia strain). The uninfected controls were ten diabetic and ten non-diabetic rats. The prepatent period was shorter in the diabetics (3.5 +/- 0.5 days) than the non-diabetics (4.2 +/- 0.4 days). Although the infected diabetic and non-diabetic rats had comparable levels of peak parasitaemia, the diabetics had significantly (P < 0.05) higher parasitaemia before this peak. The survival time was shorter (P < 0.05) for the infected diabetics (12.1 +/- 3.2 days) than for the infected non-diabetics (14.8 +/- 1.7 days). The infection did not affect the level of diabetic hyperglycaemia, but caused a more severe anaemia in the diabetics than the non-diabetics, with the percentage decreases in packed cell volume in the diabetics being higher (P < 0.05) from days 3 to 12 post-infection. In conclusion, the pathogenic effects of trypanosome infection may be more severe in rats having alloxan-induced diabetes.
用一水合四氧嘧啶（10%溶液，100毫克/千克体重）处理使20只大鼠患糖尿病。10只糖尿病大鼠和10只非糖尿病大鼠腹腔内感染相同感染剂量的布氏布氏锥虫（拉菲亚株）。未感染的对照组为10只糖尿病大鼠和10只非糖尿病大鼠。糖尿病大鼠的潜伏期（3.5±0.5天）比非糖尿病大鼠（4.2±0.4天）短。虽然感染的糖尿病大鼠和非糖尿病大鼠的最高寄生虫血症水平相当，但糖尿病大鼠在达到最高值之前的寄生虫血症水平显著更高（P<0.05）。感染的糖尿病大鼠的存活时间（12.1±3.2天）比感染的非糖尿病大鼠（14.8±1.7天）短（P<0.05）。感染不影响糖尿病大鼠的高血糖水平，但与非糖尿病大鼠相比，感染使糖尿病大鼠的贫血更严重，从感染后第3天到第12天，糖尿病大鼠的红细胞压积百分比下降更高（P<0.05）。总之，锥虫感染对四氧嘧啶诱导糖尿病大鼠的致病作用可能更严重。
