Barnett H J, Jones M W, Boughner D R, Kostuk W J
Arch Neurol. 1976 Nov;33(11):777-82. doi: 10.1001/archneur.1976.00500110045008.
Twelve patients who had no evidence of arteriosclerotic cerebral vascular disease, lacked hypertension or coagulation defect, and had not been receiving contraceptive therapy had recurrent transient cerebral ischemic attacks (TIAs) and partial nonprogressive strokes. All had prolapsing mitral valve proved by angiocardiography. The average age was 38 years, compared with 62 years in a larger series of patients with TIA associated with arteriosclerosis. We propose that the ischemic events are related to emboli emanating from the abnormal mitral valve with or without an associated paroxysmal cardiac arrhythmia.
12名患者无动脉硬化性脑血管疾病证据，无高血压或凝血缺陷，且未接受过避孕治疗，却反复出现短暂性脑缺血发作（TIA）和部分非进行性中风。所有患者经心血管造影证实有二尖瓣脱垂。平均年龄为38岁，而在一系列与动脉硬化相关的TIA患者中，平均年龄为62岁。我们认为，缺血事件与异常二尖瓣产生的栓子有关，无论是否伴有阵发性心律失常。
