Nakai M, Uchida H, Hanaoka T, Sugiyama S, Sano S, Shimizu N
Second Department of Surgery (Department of Cardiovascular Surgery), Okayama University Medical School, Okayama City, Japan.
Surg Today. 1998;28(11):1146-53. doi: 10.1007/s005950050302.
To determine the effects of prostaglandin E1 (PGE1) on the intestinal circulation, an experimental dog model of ischemic colitis following abdominal aortic reconstruction was made by ligating the inferior mesenteric artery (IMA) and the internal iliac artery, with the creation of a 50% stenosis in the superior mesenteric artery (SMA). The parameters of enteric ischemia included the blood flow of the SMA, the tissue blood flow in the small intestine and left colon, the mean stump pressure of the IMA (IMAP), and the IMAP/mean systemic blood pressure ratio. With the continuous infusion of 10 ng/kg per minute of PGE1 into the descending thoracic aorta, these values increased significantly on the seventh postoperative day compared with those on the day of operation. These results thus suggest that the continuous intraarterial infusion of PGE1 may reduce ischemic changes in the colon following abdominal aortic reconstruction.
为了确定前列腺素E1（PGE1）对肠道循环的影响，通过结扎肠系膜下动脉（IMA）和髂内动脉，并在肠系膜上动脉（SMA）中制造50%的狭窄，建立了一个腹主动脉重建术后缺血性结肠炎的实验犬模型。肠道缺血的参数包括SMA的血流量、小肠和左结肠的组织血流量、IMA的平均残端压力（IMAP）以及IMAP/平均体循环血压比值。在将每分钟10 ng/kg的PGE1持续输注到降主动脉的情况下，与手术当天相比，这些值在术后第七天显著增加。因此，这些结果表明，持续动脉内输注PGE1可能会减少腹主动脉重建术后结肠的缺血性变化。
