α-肌营养不良蛋白聚糖作为麻风分枝杆菌雪旺细胞受体的作用。

Role of alpha-dystroglycan as a Schwann cell receptor for Mycobacterium leprae.

作者信息

Rambukkana A, Yamada H, Zanazzi G, Mathus T, Salzer J L, Yurchenco P D, Campbell K P, Fischetti V A

机构信息

Laboratory of Bacterial Pathogenesis and Immunology, Rockefeller University, New York, NY 10021, USA.

出版信息

Science. 1998 Dec 11;282(5396):2076-9. doi: 10.1126/science.282.5396.2076.

DOI:10.1126/science.282.5396.2076

PMID:9851927

Abstract

alpha-Dystroglycan (alpha-DG) is a component of the dystroglycan complex, which is involved in early development and morphogenesis and in the pathogenesis of muscular dystrophies. Here, alpha-DG was shown to serve as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy. Mycobacterium leprae specifically bound to alpha-DG only in the presence of the G domain of the alpha2 chain of laminin-2. Native alpha-DG competitively inhibited the laminin-2-mediated M. leprae binding to primary Schwann cells. Thus, M. leprae may use linkage between the extracellular matrix and cytoskeleton through laminin-2 and alpha-DG for its interaction with Schwann cells.

摘要

α- dystroglycan（α-DG）是dystroglycan复合物的一个组成部分，该复合物参与早期发育、形态发生以及肌肉营养不良的发病机制。在此研究中，α-DG被证明是麻风分枝杆菌（麻风病的病原体）的施万细胞受体。只有在层粘连蛋白-2的α2链的G结构域存在的情况下，麻风分枝杆菌才会特异性地与α-DG结合。天然的α-DG竞争性抑制层粘连蛋白-2介导的麻风分枝杆菌与原代施万细胞的结合。因此，麻风分枝杆菌可能通过层粘连蛋白-2和α-DG利用细胞外基质与细胞骨架之间的连接来与施万细胞相互作用。