Passl R, Plenk H, Sauer G, Spängler H P, Radaszkiewicz T, Holle J
Arch Orthop Unfallchir. 1976 Oct 25;86(2):243-56. doi: 10.1007/BF00415336.
Homologous articular cartilage without subchondral bone instead of the usual osteochondral grafts was transplanted in sheep. The transplants were fixed to the host by a biological tissue adhesive based on fibrinogen clotting. Light- and electronmicroscopic studies showed viable transplants up to 7 months and a stable bony union with the host through endochondral bone formation. A additional external fixation of the joint after transplantation or the use of a conventional cyanoacrylate tissue adhesive failed to achieve positive results. The relations of these preliminary findings for restorative techniques of articular cartilage defects are discussed.
在绵羊身上移植了不含软骨下骨的同种异体关节软骨,以替代通常的骨软骨移植。通过基于纤维蛋白原凝血的生物组织粘合剂将移植物固定在宿主上。光镜和电镜研究显示,移植物在长达7个月的时间内保持存活,并通过软骨内骨形成与宿主实现稳定的骨结合。移植后对关节进行额外的外固定或使用传统的氰基丙烯酸酯组织粘合剂均未取得积极效果。文中讨论了这些初步研究结果与关节软骨缺损修复技术的关系。